LSD CRYSTAL CAN BE FUN FOR ANYONE

Inside the LSD-bound crystal composition, the side chain of the lid residue L209EL2 types intensive hydrophobic contacts with the two LSD and encompassing residues in TMs III, IV, and V (Determine 4C). Once the lid moved apart to expose the binding pocket in simulation, several of these contacts broke. We thus hypothesized that L209EL2 functions be